Angizem 180 mg capsules are formulations of Diltiazem hydrochloride, which is a calcium blocker agent. These are used to manage chronic stable angina (chest pain) without evidence of vasospasm in patients who remain symptomatic despite adequate doses of beta-blockers or who are unable to tolerate those agents.

The medicine may be tried along with beta-blockers in cases of chronic stable angina with normal ventricular function. When such concomitant therapy is introduced, patients taking medications must be monitored closely.  

The exact mechanism of action by which Diltiazem relieves angina has not been fully understood but is believed to be brought by vasodilator action.Due to coronary spasm, Diltiazem is known to increase myocardial oxygen delivery by dilating both coronary arteries and inhibiting coronary spasms at drug levels.   

Do not miss or take extra doses unless your doctor advises you. Take Angizem 180 exactly as your doctor has recommended you. It is taken once daily; the dosage should be individualised. The medicine is available in capsules that you need not chew or crush. Stick to the dosing schedule advised by your doctor. Ensure you do not exceed the maximum recommended dose, which is 360 mg once a day.  

In case of an overdose, contact your doctor or call your doctor even if there are no symptoms.  

If a dose of Angizem has been missed, it should be taken as soon as possible. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. 

Angizem 180 should not be used in the following conditions:

• Patients with known hypersensitivity to Diltiazem
• Patients with second- or third-degree heart blockage (AV block)
• patients with hypotension (low blood pressure)
• Patients with sick sinus syndrome
• In myocardial infarction patients
• In Pregnant women, the fetal defects and side effects associated with pregnancy have been reported.
• With concomitant use of Ivabradine
• With concomitant use of dantrolene infusion

Careful monitoring is necessary to detect the new onset of diabetes in patients with diabetes mellitus due to increased blood glucose.

The safety and effectiveness of Diltiazem in children have not been established. Administration of Angizem to elderly patients (over 65 years of age) requires caution. Elderly patients are at increased risk of side effects. These include dizziness, polyuria, palpitation, peripheral oedema, bradycardia, and rash. Therefore, particular care is advisable during the changes.

Co-administration of Diltiazem with other drugs may cause serious complications, especially in renal or hepatic impairment patients.