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|US Brand Name
|Lopinavir / Ritonavir
Lopimune 200/50 mg is a combination drug containing the active ingredients Ritonavir and Lopinavir. It is a combination medicine that works by blocking a chemical HIV protease required for HIV (Human Immunodeficiency Syndrome) to multiply. The medicine can be prescribed for children and adults above six months of age. Your doctor may prescribe Lopimune medicine with other HIV medicines to treat HIV-1 infection in adults and children 14 days of age and older. The combination medicine helps to reduce the amount of HIV medicine to treat HIV-1 in your bloodstream. It is also believed to increase the number of white blood cells called CD4 (T) cells, which helps fight off infections.
Lopimune can be consumed before or after a meal. It must not be used once daily in combination with efavirenz, nelfinavir, or nevirapine. It should not be administered daily along with phenobarbital, phenytoin, or carbamazepine. Use the HIV medicine with caution. Ritonavir/lopinavir formulation may be less effective due to decreased lopinavir plasma concentration in patients taking these agents concomitantly. Using phenytoin with this HV medicine resulted in moderate decreases in phenytoin concentrations. Lopimune must not be used once daily in paediatric patients. The once-daily treatment is not recommended in pregnant women. The combination of HIV medicine is not recommended for adult patients with three or more of the following lopinavir resistance-associated substitutions. Check with your doctor the recommended oral dose of Lopinavir/Ritonavir.
Lopimune 200/50 mg tablets should not be given once daily in paediatric patients. Let your doctor know if you are pregnant or planning to become pregnant. It is not known if Lopimune can harm your unborn baby. Tell your doctor straight away if you become pregnant while receiving HIV treatment. You should not breastfeed during the treatment. Also, you shouldn’t breastfeed a baby if you have HIV. This is because you can pass HIV to your baby. Severe liver disease, including deaths, has been reported in Lopimune 200/50 mg tablets. This is more common in those with advanced HIV disease, other liver disorders, or those taking any medications. Symptoms of severe liver disease include yellow skin and whites of eyes, fever, tiredness, nausea, pain in the upper abdomen, skin rash, dark coloured urine, and pale stools. Speak to your doctor if you get any of these symptoms. If you are taking birth control contraceptives to prevent pregnancy, you should use an alternative contraceptive measure since your HIV medicine may reduce the effectiveness of your oral contraceptive methods. Certain drugs may interact with Lopimune, and these include medicines used to treat pulmonary artery hypertension, erectile dysfunction, lower blood cholesterol, seasonal allergies, asthma, and medicines affecting the immune system.
Some common side effects of Lopimune 200/50 mg include nausea, diarrhoea, headache, vomiting, asthenia, abdominal pain, dyspepsia and feeling tired.
The above side effects, if continuing for a long time, may need medical attention. After taking medicine, some patients may suffer from liver disease. In the case of those with liver disease from before, the situation may worsen after taking medicine. Some patients may also have problems with their pancreas. Some may have a large increase in cholesterol and triglycerides. Chances of increase in blood sugar level may also happen in some patients.