Istamet 50+1000mg


US$ 0.56

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100% of 100
Pack Size Qty Price Per Pill or Unit Price Offer
30 Tablet/s US$ 0.67 US$ 20.00
60 Tablet/s US$ 0.58 US$ 35.00
90 Tablet/s US$ 0.56 US$ 50.00


SKU 1013
US Brand Name Janumet
Strength 50+1000mg
Generic Name Sitagliptin+ Metformin
Marketed By Sun Pharma, India

Description of the drug

Sitagliptin and Metformin HCL are the active ingredients in Istamet 50+1000 mg. It is an anti hyperglycemic or anti-diabetic drug that contains DPP-4 inhibitors and is administered orally to help reduce the blood sugar level.

Indications and Usage

Sitagliptin works as an effective medicine to manage diabetes by controlling the level of sugar in the body. It is generally recommended by doctors to treat type 2 diabetes mellitus either alone or in combination with other medicines. It is not advised to treat type 1 diabetes.

Dosage and Administration

1. Recommended dose:

The initial dosage for adults is 100 mg once daily. The dosage of the drug varies from one person to another. It is best to follow the doctor's advice regarding the right dosage. Do not take the medicine without your doctor's recommendation.

2. Method of Administration:

Swallow the tablet with a glass of water. It should be combined with meals for the best results. Make sure to take a balanced diet while taking the medicine. It is important to take the drug at the same time every day. This will ensure that you do not forget to take the medicine. Remember to take the medicine for as long as has been prescribed by your doctor. Keep in mind the medicine helps to control diabetes, but does not cure it.

3. Missed dose:

In case you miss to take a dose, skip the missed dose and take the next dosage at the scheduled time. Do not take two doses to make up for the missed one.

4. Overdose:

An overdose of the medicine may lead to harmful side effects, which may lead to hypoglycemia. If this is the case, you may need urgent medical help. Consult your doctor immediately if you face any of the symptoms:

Ø Back, muscle or joint pain
Ø Abdominal pain
Ø Nausea
Ø Headache
Ø Osteoarthritis
Ø Diarrhea
Ø Constipation
Ø Dizziness

Forms and Strengths

  • Form: Tablet
    • Strengths: Januvia-25 mg, Januvia 50 mg, Januvia 100 mg, Istamet 50+1000 mg, and Istamet 50+500 mg. You can buy Istamet-50+1000 mg online at a much lower price.


Stay away from the medicine if:

  • You have an allergy to Sitagliptin or other ingredients in the product
    • You are pregnant or planning to have a baby
    • You are breastfeeding
    • You have kidney problems
    • You have infections
    • You have pancreatitis

Let your doctor know about your exact medical condition and medical history. Even if you plan to purchase Istamet-50+1000 mg, first speak to your doctor.

Warnings and precautions

Lactic acidosis is a serious metabolic complication that can happen as a result of metformin accumulation while treating with Istamet. Consult your doctor before you start taking the medicine and discuss the risk factors to ensure that you are safe from the side effects.

Side effects

Some of the side effects of the medicine include:

Ø Unusual tiredness
Ø Soreness in the back of the nose
Ø Low blood sugar
Ø Fast heart rate
Ø Headache and drowsiness
Ø Feeling drunk
Ø Constipation
Ø Headache
Ø Diarrhea
Ø Unusual bleeding or bruising
Ø Dizziness and trouble concentrating

If you experience any of the symptoms, you must get immediate medical help. Inform your doctor immediately if you notice any of the symptoms.

Drug Interactions

The drug is associated with weight loss. Therefore, remember to ask your doctor if you can take diabetes and cholesterol medicines along with it. Make sure to ask your doctor about the following drugs:

Ø Probenecid
Ø Ivacaftor
Ø Non-steroidal anti-inflammatory drugs
Ø Sulfa drugs
Ø Aspirin or other salicylates
Ø Beta-blockers
Ø Monoamine oxidase inhibitors

Before you take the drugs, make sure to ask your doctor about the drugs to avoid as well as the drugs you are presently taking.


Istamet contains the two active ingredients Sitagliptin and Metformin HCL. Sitagliptin works by reducing the high blood glucose. These drugs increase the secretion of insulin and decrease the release of glucagon by the pancreas. This keeps the blood glucose levels at normal levels. When the blood glucose levels become normal, the increased changes in the glucagon and insulin stops and this prevents the hypoglycemic situation.
Metformin Hcl is an antihyperglycemic agent which decreases the glucose production from the liver, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing the glucose uptake and utilization.

Storage information

Store the medicine in a cool and dry place. Keep it out of the reach of pets and children. Also, keep it away from heat and humidity. Never use medicines that have crossed the expiry date.


It is manufactured by Merck Sharp, international manufacturer and distributor of pharmaceuticals.



You should take Istamet 50/1000 mg regularly as prescribed by your doctor. Follow the directions carefully when it comes to using the medicine. The anti-diabetic agent works best when used along with diet and regular exercise.

The dose you are given will depend on your condition, blood glucose levels, and what other medicines you take, including vitamins or herbal supplements. Taking it with meals helps to reduce the chances of an upset stomach.    

Istamet 50/1000 mg is available in the form of a tablet. Swallow the tablet with a glass of water. It should be combined with meals for the best results. Make sure to take a balanced diet while taking medicine. It is important to take the drug at the same time every day. This will ensure that you do not forget to take medicine. Remember to take medicine for as long as your doctor has prescribed it. Keep in mind that medicine helps to control diabetes but does not cure it.


Before taking the Istamet 50/1000 mg, tell your doctor if you are allergic to sitagliptin or metformin or if you have any other allergies. Before you consider an anti-diabetic agent, tell your doctor your medical history, especially of liver disease, severe breathing problems, kidney disease, stones in your gallbladder, and a disease of the pancreas. Before having surgery, tell your doctor about all the products, including prescription, non-prescription, or herbal products. You may discontinue treatment for a short time for the surgical procedure. You should consult your doctor for instructions before your surgical procedure. Limit alcohol while receiving Sitagliptin/metformin formulation because it can increase your risk of developing low blood sugar, disease of the pancreas, or lactic acidosis. High fever, water pills, diarrhoea, vomiting, or too much sweating may cause dehydration and increase your risk of lactic acidosis.

Along with its needed effects, the combination drug Istamet 50/1000 mg may cause some unwanted effects. Although not everyone experiences side effects, you may need medical attention if you get side effects associated with Istamet. You may experience dizziness, blurred vision, or dizziness due to extremely low blood glucose levels. Avoid driving or indulging in activities that require you to be attentive. Check with your doctor if any of these side effects continue or are bothersome or if you are concerned about them. More common side effects include indigestion, lack of strength, feeling of fullness, and gas in the stomach.

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