Glycomet 850mg
| Pack Size | Qty | Price Per Pill or Unit | Price | Offer | ||
|---|---|---|---|---|---|---|
| 30 Tablet/s | US$ 0.18 | US$ 5.50 |
|
|||
|
||||||
| 60 Tablet/s | US$ 0.13 | US$ 8.0027%US$ 11.00 |
|
|||
|
||||||
| 90 Tablet/s | US$ 0.13 | US$ 12.0027%US$ 16.50 |
|
|||
|
||||||
Description
| SKU | 661 |
|---|---|
| Generic For | Glucophage |
| Strength | 850mg |
| Manufacturer | Otsira |
| Active Ingredient | Metformin Hcl |
Glycomet 850mg for Diabetes Management — Trusted Generic Glucophage
Glycomet 850mg is a prescription immediate-release oral tablet containing 850mg of metformin hydrochloride, one of the most widely used and well-evidenced antidiabetic agents globally. Manufactured by USV Ltd, Glycomet 850mg is a higher-dose metformin formulation in the Glycomet range, suitable for adults with type 2 diabetes mellitus who require greater glycaemic control than is achievable at lower doses. It is prescribed either as monotherapy when lifestyle modification and lower-dose metformin have not provided adequate blood glucose control, or as a component of combination antidiabetic therapy. Glycomet 850mg delivers effective fasting and postprandial glucose lowering within the well-established, evidence-rich framework of metformin pharmacotherapy.
What is Glycomet 850mg?
Glycomet 850mg is an oral prescription tablet containing metformin hydrochloride 850mg in an immediate-release formulation. It is indicated for the management of type 2 diabetes mellitus in adults and is used as part of a comprehensive treatment plan that includes dietary modification, regular physical activity, and blood glucose monitoring. At the 850mg dose, metformin provides more intensive hepatic glucose suppression and insulin sensitisation than the 250mg or 500mg strengths, making it appropriate for patients whose HbA1c remains above target despite lower-dose treatment. The standard clinical dosing regimen for metformin 850mg is twice daily (with breakfast and evening meal), providing a total daily dose of 1700mg — sufficient for clinically meaningful HbA1c reduction in most patients. It may be further combined with other antidiabetic agents for patients requiring additional glycaemic control.
Manufacturer: Glycomet 850mg is manufactured by USV Ltd, an established Indian pharmaceutical company with extensive experience in metabolic disease management and a long-standing commitment to high-quality, affordable antidiabetic medicines.
The Active Ingredient, Metformin, and Its Working Mechanism
Metformin hydrochloride at 850mg operates through the same well-characterised biguanide mechanisms as at lower doses, but with a proportionally greater pharmacodynamic effect. Its primary action is the suppression of hepatic gluconeogenesis and glycogenolysis — the processes by which the liver generates and releases glucose into the circulation. In type 2 diabetes, hepatic insulin resistance leads to pathological overproduction of glucose, particularly overnight, resulting in elevated fasting blood glucose levels. Metformin 850mg inhibits this process substantially, reducing fasting plasma glucose by approximately 3–4 mmol/L at therapeutic doses. Peripheral insulin sensitisation in skeletal muscle improves glucose uptake in response to existing insulin levels, and mild reduction in intestinal glucose absorption provides an additional postprandial benefit. At the molecular level, metformin activates AMPK and inhibits mitochondrial complex I in hepatocytes, depleting hepatic energy supply and suppressing anabolic glucose-producing pathways without stimulating insulin secretion.
Clinical Uses of Metformin 850mg Tablets
Glycomet 850mg is indicated as a second-step oral diabetes medicine for adults with type 2 diabetes when lower metformin doses or initial monotherapy have been insufficient to achieve HbA1c targets. It is commonly used in combination with sulfonylureas (glipizide, glibenclamide), DPP-4 inhibitors (sitagliptin, vildagliptin), SGLT-2 inhibitors (dapagliflozin, empagliflozin), GLP-1 receptor agonists, and insulin. Metformin 850mg is also used in polycystic ovary syndrome (PCOS) for its insulin-sensitising effects, which reduce androgen levels, restore menstrual regularity, and improve fertility outcomes in affected women. Pre-diabetic patients at high risk of T2DM progression may receive metformin as preventative therapy under specialist guidance. The 10-tablet pack (Glycomet 850mg) provides a 5-day supply at twice-daily dosing, suitable for short prescription cycles or trial periods.
Brand vs Generic Differences: Glycomet vs Generic Metformin 850mg
Glucophage and Glycomet 850 both contain metformin and are commonly prescribed to manage type 2 diabetes by lowering blood sugar levels. Glucophage is the original branded formulation with a long clinical history and established quality standards. Glycomet 850 is a generic alternative that offers similar effectiveness at a lower cost. Both medicines work by reducing liver glucose production and improving insulin sensitivity. While their therapeutic action is essentially the same, slight differences may occur in inactive ingredients, tablet formulation, tolerance, and pricing depending on the manufacturer and patient response.
Related Strengths and Products
In addition to Glycomet 850mg, Glycomet 250mg, Glycomet 500mg SR, and Glycomet SR 1000mg, Glycomet 500 mg SR and Glycomet SR 1000 mg are available, catering to the full spectrum of metformin dosing from initiation to maximum therapy. For patients on Glycomet 850mg twice daily who require dose escalation, transitioning to Glycomet 1GM SR once or twice daily may improve tolerability while achieving higher total daily doses. Combination preparations such as Glycomet GP (500+1) and Glycomet GP (500+2) combine metformin with glipizide to achieve dual oral antidiabetic action.
Key Benefits of Glycomet 850mg
Glycomet 850mg provides clinically meaningful HbA1c reduction — typically 1.5–2.0% below baseline — through its intensified hepatic glucose suppression and insulin sensitisation. As with all metformin formulations, it carries no intrinsic risk of hypoglycaemia when used as monotherapy, a significant safety advantage over sulfonylureas and insulin in patients prone to hypoglycaemic events. Its neutral or modest weight-reducing effect is a meaningful clinical benefit in the predominantly overweight and obese T2DM population. The long-term cardiovascular protective effects of metformin, including reductions in cardiovascular event risk and all-cause mortality demonstrated in the UKPDS trial, are relevant at effective therapeutic doses such as 850mg. Additionally, beneficial effects on lipid profiles (lower LDL and triglycerides) contribute to reduced cardiometabolic risk.
Dosage Advice and Storage
Take Glycomet 850mg orally with meals — ideally with breakfast and the evening meal for a twice-daily regimen. Always swallow the tablet whole with a full glass of water; do not crush or chew. Taking metformin with food is essential at the 850mg dose to minimise the risk of gastrointestinal side effects, which are more pronounced at higher doses and on an empty stomach. Blood glucose monitoring should guide dosing frequency and the need for additional antidiabetic agents. HbA1c should be reviewed at 3-monthly intervals until stable. Renal function (eGFR) must be assessed before treatment initiation and at least annually during treatment — more frequently in patients with borderline renal function or in those using nephrotoxic medications. Do not exceed the maximum recommended daily dose of metformin (typically 3000mg/day). Store below 25°C in a dry, light-protected location.
Warnings and Drug Interactions Related to Metformin 850mg
The contraindications and precautions for Glycomet 850mg are consistent with all metformin formulations. Absolute contraindications include eGFR below 30 mL/min/1.73m², severe hepatic impairment, and acute or chronic metabolic acidosis. Temporary discontinuation is required before iodinated contrast agent administration (withhold 48 hours before; resume after confirming normal renal function post-procedure) and before major surgery under general anaesthesia. At the higher 850mg dose, the risk of gastrointestinal side effects is greater than at lower doses, emphasising the importance of meal-time administration and gradual dose titration. Alcohol substantially increases the risk of lactic acidosis and should be avoided. Vitamin B12 levels should be monitored annually with long-term use. Drug interactions of significance include cimetidine (reduces metformin renal clearance), alcohol, and iodinated contrast media.
Side Effects Associated with Metformin 850mg Tablets
At 850mg, the gastrointestinal side effects of metformin — nausea, vomiting, diarrhoea, flatulence, and abdominal discomfort — occur with higher frequency than at lower doses, particularly during the first few weeks of treatment and if taken without food. Starting at a lower dose and titrating gradually to 850mg substantially reduces the incidence of these effects. Most gastrointestinal symptoms resolve with continued use. Metallic taste is common and transient. Hypoglycaemia does not occur with metformin monotherapy. Vitamin B12 deficiency from long-term therapy may manifest as peripheral neuropathy or megaloblastic anaemia and requires periodic monitoring. Lactic acidosis, the most serious adverse event, remains very rare at standard doses in patients without contraindications but demands clinical awareness.
Where to Buy Authentic Glycomet 850mg Online?
ReliableRxPharmacy is a reliable, trusted online pharmacy offering genuine Glycomet 850mg from USV Ltd at affordable, competitive prices, with worldwide shipping. Products are sourced from certified pharmaceutical manufacturers, ensuring quality and authenticity with every order. ReliableRxPharmacy provides a secure platform for managing your diabetes prescriptions online, with convenient prescription upload, discreet packaging, and knowledgeable customer support — making it the preferred destination for patients committed to consistent, effective diabetes management.
20% OFF
Terms and Conditions Apply*
Flat 20% OFF
on your first purchase
20% off only on the product value
Maximum discount value $20
Only one coupon can be used at a time
Coupon code will be mailed on
your registered email address.
Login
Sign up
Flat 20% OFF
on your first purchase
20% off only on the product value
Maximum discount value $20
Only one coupon can be used at a time
Coupon code will be mailed on
your registered email address.
Login
Sign Up
Flat 20% OFF
on your first purchase
20% off only on the product value
Maximum discount value $20
Only one coupon can be used at a time
Coupon code will be mailed on
your registered email address.
Forgot Password ?