Sazo EN 500 mg is highly prescribed by doctors for treating rheumatoid arthritis, Crohn’s disease, ulcers, psoriatic arthritis, and inflammation related to bowel disease. In several cases, this drug has also been reported to treat the ailment caused by liver cirrhosis to the hepatocyte liver cells. Sazo EN tablets are predominantly composed of anti–inflammatory potent metabolite called Sulphasalazine, which belongs to a class known as DMARD or disease-modifying anti-rheumatic drug. It effectively reduces pain, inflammation, and swelling in your joints and may reduce the progression of the disease. Sulfasalazine will not begin to work immediately; it will take 1 to 3 months to notice any improvement in your symptoms.

Sazo EN 500 mg is available as a tablet and should be consumed in the prescribed dosage orally with enough water. Do not take this medicine with fluid other than water, like juice and milk, as this can cause some problems related to the blood sugar level. The recommended dose of this drug for adults is 500 mg once daily, or depending on the body weight, the recommended dose of Sulphasalazine for children should get prescribed. Patients should be instructed to take the medicine in evenly divided doses, preferably after meals; in addition, patients should be advised that the medicine may produce yellow to orange discolouration of the urine or skin. Consult a doctor before giving this medicine to patients below 18. The dose should be adjusted gradually within one to two weeks but after consulting a doctor.

Sazo EN 500 mg is known to contraindicate in the following cases:

    —   Hypersensitive reactions

    —   Intestinal or urinary obstruction

    —   Children below two years of age

Sulfasalazine should be used cautiously in patients with severe allergies or bronchial asthma. Adequate fluid intake must be maintained to prevent stone formation. Avoid consuming alcohol while taking Sulfasalazine. Check with your doctor before you begin any new medication. Some drugs may interact with Sazo EN 500 mg; tell your doctor if you are taking any of the following medicines:

    —   High blood sugar, such as metformin or glibenclamide

    —   Methenamine, an antibiotic for treating urinary tract infection

    —   Digoxin for heart failure

    —   Folic acid

    —   Mercaptopurine and azathioprine suppress your body’s immune response in organ transplantation and rheumatoid arthritis.

    —   Do not use complementary treatments such as herbal preparations without discussing them with your doctor, as some could react to Sazo EN. You can keep on taking medicine if required as prescribed.

Discussing with your healthcare provider is best before undergoing an operation or receiving a vaccination.

The side effects are prescribed as follows:

    —   Immediate hypersensitivity reactions

    —   Worsening of narrow-angle glaucoma

    —   Paradoxical bronchospasm

    —   Worsening of urinary retention

Patients should be informed of possible side effects and the need for careful medical supervision. The occurrence of sore throat, jaundice, and fever may indicate a serious blood disorder. If any of these occur, the patients should seek immediate medical advice.