|Price Per Pill or Unit
|US Brand Name
|Clindamycin 1% and Benzoyl Peroxide 5%
|Ajanta Pharma, India
Peroclin gel 5% contains two medicines, clindamycin and benzoyl peroxide. It is categorized under the class of medicines known as anti-acne formulations. The medicine is indicated for treating mild to moderate acne on your skin. Clindamycin is an antibiotic that stops bacteria involved in acne from growing, whereas benzoyl peroxide can effectively get rid of bacteria and dead skin called, which clogs skin pores.
Peroclin gel should be applied two times a day, morning, and evening, or as directed by a doctor, to affected areas after the skin is gently washed, rinse with water and pat it dry. The gel is for topical use only, not for ophthalmic purposes. Concomitant topical acne treatment should be used cautiously because irritation may occur, especially with peeling or abrasive agents.
The use of antibiotics may be associated with the overgrowth of non-susceptible organisms, including fungi. If this happens, discontinue treatment, and take appropriate measures. Avoid contact with eyes, nose, and mouth.
Peroclin gel is to be used as directed by the doctor. It is for topical use only. Avoid contact with the eyes and inside the nose, mouth, and all mucus membranes, as this topical formulation may be irritating. This medicine should not be used for any disease other than prescribed. Patients should avoid using any other topical acne formulation unless directed by their doctor. Patients should minimize or avoid exposure to sunlight while using clindamycin and benzoyl peroxide gel. To minimize exposure to sunlight, wear a wide-brimmed cap or other protective clothing, and sunscreen with SPF 15 or higher should be used. Patients who develop allergic symptoms such as severe swelling or difficulty breathing should discontinue Peroclin gel and contact their doctor immediately. The combination gel formulation may bleach hair or colored fabric.
Peroclin gel should not be used in people who have shown hypersensitivity to benzoyl peroxide, clindamycin, or lincomycin. It is also contraindicated in those having a history of ulcerative colitis, regional enteritis, or antibiotic-associated colitis.
There are no well-controlled trials in pregnant women treated with benzoyl peroxide/clindamycin. Also, it is unknown whether Peroclin gel can cause fetal harm when given to pregnant women.
It is unknown whether the combination medicine is excreted in breast milk after topical use. However, orally administered clindamycin has been reported to appear in breast milk. Because of the potential for serious adverse effects in infants, a decision should be made on whether to discontinue treatment, considering the importance of the drug to the mother. Avoid using erythromycin with clindamycin-containing products.
During clinical trials, dry skin was the most frequently reported side effect of Peroclin gel. Other local adverse events reported in patients in the clindamycin and benzoyl peroxide include application site reaction, pruritus, peeling, sunburn, and erythema. The incidence of dry skin can be reduced by using a moisturizer. Anaphylaxis and allergic reactions leading to hospitalization have been reported using Peroclin gel.