|Pack Size||Qty||Price Per Pill or Unit||Price||Offer|
|1 Tube/s||US$ 7.00||US$ 7.00||
|3 Tube/s||US$ 7.00||US$ 21.00||
|6 Tube/s||US$ 7.00||US$ 42.00||
|US Brand Name||Differin|
Adaferin gel 0.1% is a prescription medicine for acne vulgaris people 12 years of age and older. It contains the active ingredient Adapalene, a naphthoic acid derivative with retinoid-like pharmacological properties. It possesses modulatory and anti-inflammatory effects. The drug can be used as a single agent in mild acne or combination with antimicrobial agents in inflammatory acne and has proved to be effective as a maintenance treatment. As compared to other retinoids, Adapalene has a rapid onset of action and a particular tolerability profile. The drug is, therefore, assured of a role in the first-line treatment of acne vulgaris.
Mode of action
Adaferin gel comprises an active ingredient called Adapalene that adheres to specific retinoic acid and nuclear receptors but does not adhere to the cytosolic receptor protein. According to the pharmacological profile, the drug modifies cellular differentiation, inflammatory process, and keratinization. However, the importance of these findings of the mode of action of Adapalene for the treatment of acne vulgaris is unknown.
Adapalene gel should be applied once daily to affected areas of your skin after washing in the evening before retiring.
During the initial days of the treatment, an apparent worsening of acne may occur. It can be due to the action of the medicine on previously unseen lesions and should not be considered a reason to stop the treatment. Wash the area where Adaferin gel will be applied with a non-medicated soap and pat dry. Avoid application of the areas of skin around lips, eyes, and mouth. Squeeze a small amount onto your fingertips and spread a thin layer of gel over the entire area of the face and other affected areas of your skin.
A mild, temporary sensation of warmth and slight stinging may occur shortly after applying the gel. You may use moisturizers for the relief of irritation or dry skin. Patients should be instructed to minimize sun exposure.
Exposure to sunlight should be minimized during the treatment with Adapalene gel. Patients with inherent sensitivity to the sun and those who normally experience high skin exposure levels should be warned to exercise caution. Use of sunscreen lotions and protective clothing is recommended when exposure cannot be avoided.
Certain cutaneous reactions such as dryness, scaling, burning, erythema may occur. These reactions are likely to occur during the first two to four weeks of treatment, are mostly mild to moderate, and usually reduces with continued use of the medicine. Depending on the severity of these adverse effects, patients should be instructed to use an oil-free moisturizer or reduce the frequency of application of Adapalene gel. If patients use cosmetics, these should be non-astringent and non-comedogenic. The gel should not be applied to abrasions, cuts, or sunburned skin. Reactions characterized by symptoms such as facial edema, lip swelling, pruritis, eyelid edema may also occur during the treatment. A patient should stop using Adapalene gel and consult a doctor if experiencing allergic reactions.
Some side effects such as dryness, peeling, erythema, burning, and pruritis have been reported. These are mostly seen during the first month of treatment and decrease in frequency after that. Always talk to your doctor if the side effects get worse.