|Pack Size||Qty||Price Per Pill or Unit||Price||Offer|
|8 Capsule/s||US$ 1.59||US$ 12.71||
|US Brand Name||Etoposid|
Description of the drug
Etoposide is an effective anti-cancer medicine (antineoplastic or cytotoxic) that interferes with the growth of cancer cells and slows their growth and spread in the body. Posid is an inhibitor of the enzyme topoisomerase II that is used as a form of chemotherapy for malignancies such as lung cancer, testicular cancer, lymphoma, Ewing's sarcoma, non-lymphocytic leukemia, and glioblastoma multiforme.
Doctors can prescribe this drug with other medications and, in some cases, it’s used in a condition of bone marrow or blood stem cell transplant. Etoposide is an antibiotic that can prevent certain bacterial infections of the lungs, skin, bones, joints, genitals, bladder and the digestive system. This drug belongs to a group of antibiotics called ‘quinolones.’
Indications and Usage:
Etoposide is an active ingredient of Posid, and its chemical make-up derives from podophyllotoxin, a toxin found in the American Mayapple. This ingredient works by blocking the action of an enzyme in cells called topoisomerase II. The body cells take this enzyme to keep their DNA in the proper shape when they go through division process. The absence of this enzyme could cause the death of cells because cancer cells divide more quickly than normal cells, they are more likely than normal cells to be affected by Etoposide.
Etoposide is prescribed alone or in combination with other drugs to diagnose certain forms of lung cancer and other cancerous cells. It also slows down the growth of cancer cells. This medication can be prescribed to treat certain types of testicular cancer, leukemias and lymphomas, ovarian cancer, and prostate cancer.
Dosage and Administration:
- Recommended dose:
Etoposide is usually given as a course of several cycles of treatment. The exact dosage depends on which cancer you have. Etoposide injection (also known as VP-16) is used in combination with other cancer medicines. Your doctor can tell you exactly how much amount of this medicine is needed to treat the problem. The oral dose is twice the IV dose rounded to the nearest 50 mg and given in 2 divided doses if greater than 400 mg. For combination therapy, 50-100 mg/m 2 BSA/day from days 1-5, or 100 mg/m 2 on days 1, 3 and 5 is usually prescribed.
- Method of Administration:
Etoposide is available as capsules, tablet or as a form of fluid as an infusion into the vein (intravenous, IV). It’s also considered an irritant that can cause inflammation of the vein through which it is given, so it can cause tissue damage. Your nurse or doctor has to be trained to administer this drug. If you experience pain, redness or swelling at the IV site while receiving Etoposide, inform your doctor about it immediately.
- Missed dose
If you have missed its dose, then try to take it as soon as you remember it. But, if you are close to the next dose, then don’t double its amount. Don’t skip your regular dose and don’t increase the amount for the missed dose.
Usually, patients receive 3 to 4 cycles of chemotherapy, so the dose and the number of cycles of therapy should be adjusted according to the level of bone marrow suppression and the reaction of the tumor. Its overdose can arouse myelosuppressive effects, so it should be taken into account when determining the dosage of Etoposide.
Forms and Strengths:
Etoposide is available in 50mg and 100mg doses under the brand name ‘Posid’.
In rare cases, this drug may cause damage to certain nerves in the body, which can lead to a condition called peripheral neuropathy. Its dosage has to be recommended by the doctors.
Warnings and precautions:
- If you are pregnant, trying to get pregnant, or if there is any chance of pregnancy. This drug may cause problems with the fetus if taken at the time of conception or during pregnancy.
- Tell your doctor and pharmacist if you have a history of allergy to Etoposide or any other medications. Ask your pharmacist to know the ingredients of this medicine.
- Keep tan on your blood pressure during treatment.
- This can increase your chance of getting an infection, so let your doctor right away if you have any signs of infection.
- Please do not have immunizations/vaccinations without the consent of your doctor and try to avoid contact with people who have recently received live vaccines.
- Limit alcoholic beverages and, if possible, avoid daily use of alcohol while using this medicine may increase your risk of stomach bleeding.
- Get plenty of rest and maintain good nutrition.
Etoposide is not recommended for pregnant women as it may harm an unborn baby. Consult your doctor for more details and to discuss the use of reliable forms of birth control measures or contraceptives while taking this medication.
This medication passes into breast milk and breastfeeding can be dangerous while taking Etoposide.
There are some possible side effects of Etoposide, such as:
- Loss of appetite or weight
- Hair loss
- Pain, burning or tingling in the hands or feet
- Unusual tiredness or weakness
- Pale skin
- Sores in the mouth and throat
- Stomach pain
- Eye pain
- Vision problems
Some severe side effects of this medication can be:
- Shortness of breath
- Fast, irregular, or pounding heartbeat
- Waves of seizures
- Pink eyes, yellowing of the skin or eyes
You will come across some more side effects while browsing for Posid 50 mg.
Patients have to be checked regularly by a health care professional while they are taking Etoposide, to monitor side effects and check your response to therapy. Check-up for the periodic blood work to monitor your complete blood count (CBC) and the function of other organs can be ordered by your doctor. Do not start, stop, or change the dosage of any medicines being taken along with Etoposide without your doctor's approval.
Etoposide is a semisynthetic derivative of podophyllotoxin. This drug belongs to a class of chemotherapy drugs called plant alkaloids. Plant alkaloids are made from plants. It is very soluble in methanol and chloroform, slightly soluble in ethanol and sparingly soluble in water and ether. It is made more miscible with water by means of organic solvents. It has a molecular weight of 588.58 and a molecular formula of C29H32O13.
Podophyllotoxins and camptothecin analogs are also known as topoisomerase inhibitors. The plant alkaloids are cell-cycle specific that attack the cells during various phases of division.
Keep Posid in the container it came in, in the refrigerator (do not freeze), tightly closed, and out of reach of children. Don’t use any medication of expiry dates and dispose of it properly.
Posid is manufactured by Cadila Pharmaceuticals Limited, an India-based pharmaceutical company. This US FDA approved company is headquartered in Ahmedabad and supplies API and formulations. You can easily buy Posid 50 mg online from our website and have it delivered at your doorstep.