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Description
| SKU | 1467 |
|---|---|
| Generic For | Kombiglyze |
| Strength | 5/500 mg |
| Manufacturer | Astra Zeneca Italy |
| Active Ingredient | Sexaglitptin |
Kombiglyze XR 5/500 mg for Diabetes Management — Order Online
Kombiglyze XR 5/500 mg is a combination therapy to treat type 2 diabetes. The medicine effectively controls high blood sugar levels in a patient with type 2 diabetes mellitus. It is a prescription medication to prevent diabetes complications like kidney damage, the chance of stroke or heart attack, and blindness.
The drug's active ingredients are Metformin (500 mg) and Saxagliptin (5 mg). The medicine works by decreasing the amount of glucose in the blood, thereby controlling the amount. It also works by increasing the amount of two incretin hormones in the body.
Kombiglyze can be prescribed alone or in combination with other diabetes drugs. All diabetes medications work best with a healthy diet and regular exercise.
The drug is an oral anti-diabetic which belongs to a class of medicine called dipeptidyl peptidase-4 (DPP-4) inhibitors.
The recommended dose will depend on several factors; your doctor will prescribe the right dosage for you considering your health condition, blood sugar levels and what other medication a patient may be taking. The dose should not be fixed without consulting a doctor, as it may lead to adverse health effects.
Taking this medicine with meals helps to reduce the chances of developing an upset stomach.
 — Do not take the medicines if you are allergic to the main ingredient or any other drug ingredient.
 — Do not share your medicine with anyone, even if the person suffers from the same symptoms.
 — Use the medicine only for specified purposes and not for any other purpose.
 — Tell your doctor if you are taking any anti-diabetic drug called sulphonylurea or insulin. If so, your doctor will reduce the dose because it may lead to excessively low blood glucose.
 — Tell your doctor if you have liver, heart, or kidney disease or are suffering from other ailments. Disclosing the medicines, you are taking currently should also be done to avoid drug interaction.
 — Don’t hesitate to visit a doctor if you find no relief even after taking the medicines.
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Drug Interactions:
Several medicines may interact with Kombiglyze Xr Tablet if taken together, thereby increasing or decreasing the medicine's working. Mention all medication your doctor that you may take to avoid drug interaction.Â
Some of the common side effects of the medicine include:
- Abdominal pain
- Altered sense of taste, including metallic taste
- Diarrhoea
- Gastroenteritis
- Upper respiratory infection
- Inflammation of air cavities around the nose and sore throat
- Severe allergic reaction
- Headache
- Fatigue
- Urinary tract infection
- Urge to vomit
- Low blood sugar levels
- Rash
This is not a complete list of medicines that may interact. There are other medicines as well. If the side effects persist, you must get in touch with your doctor as soon as possible.
What is Kombiglyze XR 5/500 mg used for?
Kombiglyze XR 5/500 mg is used to treat type 2 diabetes. It contains two medicines that work together: saxagliptin (a medicine that helps your pancreas release insulin when blood sugar rises) and metformin (a medicine that reduces glucose production in your liver and improves how your body uses insulin). You take it by mouth, usually once or twice daily with food, as part of a treatment plan that includes diet and exercise to help control your blood sugar levels.
How does Kombiglyze XR 5/500 mg work in the body?
Kombiglyze XR combines two medicines that help control blood sugar in type 2 diabetes. Saxagliptin works by increasing hormones that help your pancreas release insulin when blood sugar rises. Metformin (the 500 mg part) reduces the amount of sugar your liver makes and helps your body use insulin better. Together, they lower your blood sugar levels throughout the day. The XR means the medicine releases slowly over time, so you take it once daily.
How long should I keep using Kombiglyze XR 5/500 mg?
Kombiglyze XR 5/500 mg is a long-term diabetes medicine, so you'll typically keep taking it for months or years to help control your blood sugar. Your doctor will decide how long you need it based on how well it works for you and your overall health. Do not stop taking it without talking to your doctor first, even if you feel better—stopping suddenly can cause your blood sugar to rise dangerously. Your doctor will review your treatment regularly and may adjust or change your medicine if needed.
What should I do if I forget to take a dose of Kombiglyze XR 5/500 mg?
Take the missed dose as soon as you remember, unless it's almost time for your next scheduled dose. If it's nearly time for your next dose, skip the missed one and continue with your regular timetable. Never double up on doses to make up for a forgotten one. If you're unsure about timing, contact your pharmacist or doctor for guidance. Keeping to a consistent routine helps you remember to take your tablet each day.
What things can affect how well Kombiglyze XR 5/500 mg works?
Several factors can affect how well Kombiglyze XR works for you. Your liver and kidney function influence how your body processes the medicine—if either organ isn't working properly, the medication may be less effective or build up in your system. Certain medicines, like some diuretics (water pills) or corticosteroids (anti-inflammatory drugs), can interfere with how well it controls blood sugar. Your diet, exercise level, and stress also play important roles—eating healthy foods, staying active, and managing stress help the medicine work better. Alcohol may affect blood sugar control too. Always tell your doctor about all medicines you take and any health conditions.
How will I know if Kombiglyze XR 5/500 mg is working for me?
You'll know Kombiglyze XR is working when your blood sugar levels become more stable and easier to control. Your doctor will check this with regular blood tests, particularly your HbA1c (a test showing your average blood sugar over three months). You may also notice fewer symptoms like excessive thirst, tiredness, or frequent urination as your blood sugar improves. Weight changes may occur too. Only your doctor can confirm the medicine is working effectively by reviewing your test results and how you feel overall—don't judge effectiveness by symptoms alone, as high blood sugar often causes no obvious signs.
What are the common side effects of Kombiglyze XR 5/500 mg, and should I be worried?
Kombiglyze XR may cause headache, dizziness, nausea, or stomach upset as common side effects. Most are mild and often improve as your body adjusts. Low blood sugar is possible, especially if you also take other diabetes medicines—watch for shaking, sweating, or confusion. Serious side effects are rare but include severe joint pain or signs of pancreas problems (severe stomach pain, vomiting). Stop taking it and contact your doctor immediately if you experience serious symptoms. Always discuss any concerns with your doctor before making changes to your treatment.
Is it safe to use Kombiglyze XR 5/500 mg for a long period of time?
Kombiglyze XR 5/500 mg is designed for long-term use in managing type 2 diabetes. Many patients take it safely for years under medical supervision. However, your doctor will monitor your kidney function, blood sugar levels, and overall health regularly to ensure it remains safe and effective for you. Do not stop or change your dose without speaking to your doctor first. If you experience any unusual symptoms, report them to your healthcare provider immediately.
Can I use Kombiglyze XR 5/500 mg alongside my other medicines or supplements?
Before using Kombiglyze XR with other medicines or supplements, talk to your doctor or pharmacist. Certain medications can interact with saxagliptin (the diabetes medicine in Kombiglyze XR), affecting how well it works or increasing side effects. This includes some blood pressure medicines, certain antibiotics, and antifungal drugs. Some supplements may also interact. Your healthcare provider knows your complete medical history and can safely advise which combinations are appropriate for you. Never start or stop any medicine without consulting them first.
Is it safe to drink alcohol while taking Kombiglyze XR 5/500 mg?
Drinking alcohol while taking Kombiglyze XR can increase your risk of low blood sugar and may cause dizziness or weakness. Alcohol can also affect how your body processes the medicine. If you choose to drink, limit yourself to moderate amounts and eat food with any alcohol. Always talk to your doctor or pharmacist about your drinking habits before starting this medicine, as they can give you personalised guidance based on your health. Avoid binge drinking.
Can older adults or children use Kombiglyze XR 5/500 mg safely?
Kombiglyze XR is not recommended for children—it's designed only for adults with type 2 diabetes. Older adults can use it safely, but your doctor may start you on a lower dose if you have kidney problems, which are more common with age. Your kidney function affects how your body processes this medicine. Always tell your doctor about any other health conditions or medicines you take. Your doctor will decide the right dose for you based on your individual health needs.
Do I need a different dose of Kombiglyze XR 5/500 mg if I have kidney or liver problems?
Yes, your dose may need to change if you have kidney or liver problems. Kidney problems are more important — if your kidneys don't work well, your doctor may lower your dose or choose a different medicine. Liver problems may also require dose adjustment. Do not change your dose yourself. Tell your doctor about any kidney or liver problems before you start taking Kombiglyze XR, and ask them what dose is safe for you.
What are my options if Kombiglyze XR 5/500 mg does not agree with me?
If Kombiglyze XR 5/500 mg does not agree with you, speak with your doctor. They can adjust your dose, switch you to a different medicine, or try an alternative diabetes treatment that suits you better. Do not stop taking it on your own without medical advice, as this may affect your blood sugar control. Your doctor will help find the right option for your needs and monitor your response carefully.
How does Kombiglyze XR 5/500 mg compare to other treatments used for the same condition?
Kombiglyze XR combines two medicines—saxagliptin (a DPP-4 inhibitor that helps your pancreas release insulin) and metformin (which reduces sugar production in your liver). Unlike single-ingredient medicines, this combination addresses diabetes in two different ways simultaneously. Some patients benefit from the convenience of one tablet instead of two separate ones. However, the best treatment depends on your blood sugar levels, kidney function, and other health conditions. Your doctor will decide if Kombiglyze XR suits you better than alternatives. Always discuss treatment options with your healthcare provider before making changes.
How do I safely dispose of leftover or out-of-date Kombiglyze XR 5/500 mg?
Do not flush Kombiglyze XR down the toilet or throw it in household waste. The safest way to dispose of leftover or out-of-date tablets is to take them to a pharmacy or designated medicine disposal facility in your area. Most pharmacies accept unused medicines for free, regardless of where you bought them. If no facility is available locally, mix the tablets with unpalatable substances like coffee grounds in a sealed bag before putting them in household waste. Check with your local waste management authority for specific disposal guidelines in your region.
How should I store Kombiglyze XR 5/500 mg at home, and what happens if it expires?
Store Kombiglyze XR in a cool, dry place away from direct sunlight and heat. Keep it in its original container with the lid tightly closed. Do not freeze. After the expiration date, the medicine may lose potency and become less effective at controlling your blood sugar. Do not use expired Kombiglyze XR. Dispose of it safely according to your local pharmacy's guidelines, or ask your pharmacist how to dispose of unused medicine properly.
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