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Description
| SKU | 1468 |
|---|---|
| Generic For | Kombiglyze |
| Strength | 5/1000mg |
| Active Ingredient | Sexaglitptin |
Kombiglyze XR 5/1000 mg for Diabetes Management — Order Online
Kombiglyze XR 1000 mg contains two active ingredients; saxagliptin and metformin. It is used as an adjunct to diet and exercise to improve glucose levels in adults with type 2 diabetes when treatment with both saxagliptin and metformin is appropriate.
Generally, Kombiglyze XR should be administered once daily with the evening meal, with a gradual dose reduction to reduce the gastrointestinal effects of metformin. Be sure to consult your doctor before taking this medicine.
Kombiglyze XR has been contraindicated in patients with renal insufficiency, acute or chronic metabolic acidosis, hypersensitivity to metformin hydrochloride, history of serious hypersensitivity reaction to Kombiglyze extended-release tablet. Lactic acidosis is rare, but serious complications can occur due to metformin accumulation during the treatment. If lactic acidosis is suspected, the combination antidiabetic agent should be discontinued, and the patient should be hospitalised immediately. If pancreatitis (inflammation of the pancreas) is suspected, Kombiglyze XR should be discontinued, and appropriate management should be started.
Patients are advised to report symptoms of heart failure immediately. If heart failure develops, consider discontinuation of saxagliptin/metformin. The use of Kombiglyze XR is known to cause hypoglycaemia. Therefore, when insulin is used in combination with saxagliptin, a lower insulin dose may be required to reduce the risk of hypoglycaemia. The combination antidiabetic agent should be used only during pregnancy if needed. Because Saxagliptin/metformin are secreted in breast milk, caution should be taken when the antidiabetic agent is given to a nursing woman. The safety and effectiveness of this drug have not been established in children.
Nausea, vomiting, diarrhoea, headache, upper respiratory tract infection, hypersensitivity reactions, nasopharyngitis, infections, and acute pancreatitis. Hypoglycaemia (low blood sugar may be seen in people receiving insulin, such as sulphonylureas and in really impaired patients.
What is Kombiglyze XR 5/1000 mg used for?
Kombiglyze XR 5/1000 mg contains two medicines that work together to control blood sugar levels in type 2 diabetes [a condition where your body cannot use insulin properly]. Saxagliptin helps your pancreas release insulin when blood sugar is high, while metformin reduces how much sugar your liver makes and helps your body use insulin better. Your doctor may prescribe this tablet alongside diet and exercise to lower your blood sugar and reduce the risk of diabetes complications.
Who is Kombiglyze XR 5/1000 mg meant for, and is it right for me?
Kombiglyze XR 5/1000 mg is for adults with type 2 diabetes (high blood sugar) when diet and exercise alone aren't enough. It combines two medicines to help control blood sugar levels. Your doctor prescribes it based on your blood sugar readings, kidney function, and other medicines you take. It's not suitable if you have type 1 diabetes, severe kidney problems, or diabetic ketoacidosis (a serious condition). Only your doctor can confirm whether this medicine is right for you—discuss your complete medical history and current medications with them before starting.
Should I take Kombiglyze XR 5/1000 mg with food, and does the time of day matter?
You can take Kombiglyze XR with or without food—eating doesn't affect how well it works. However, take it at the same time each day to help you remember your dose and keep your blood sugar levels steady. Morning or evening both work fine; choose whichever fits your routine best. If your doctor has given you specific instructions about timing or food, follow those instead. Ask your pharmacist if you're unsure about the best time for your schedule.
How much Kombiglyze XR 5/1000 mg should I take, and how often?
Take one tablet of Kombiglyze XR 5/1000 mg by mouth once daily, preferably with your first meal of the day. Your doctor may adjust your dose based on your blood sugar levels and how well you tolerate the medicine. Never take more than one tablet daily unless your doctor tells you to. Always follow your doctor's instructions exactly, as the right dose depends on your individual needs and other medicines you take.
Is Kombiglyze XR 5/1000 mg suitable for long-term use, or is it a short-term treatment?
Kombiglyze XR 5/1000 mg is designed for long-term use in managing type 2 diabetes. You take it regularly as a maintenance treatment to help control your blood sugar levels over months and years, not as a short-term therapy. Your doctor will monitor how well it works for you and may adjust your dose if needed. Continue taking it exactly as prescribed unless your doctor tells you otherwise. Long-term use is safe when taken as directed and combined with diet and exercise changes.
How quickly will I notice Kombiglyze XR 5/1000 mg working?
Kombiglyze XR 5/1000 mg typically takes 1–2 weeks to show initial effects on your blood sugar levels, though it may take 2–3 months to reach its full benefit. You won't feel the medicine working — instead, your doctor will see improvements in your blood sugar readings during check-ups. Keep taking your tablet exactly as prescribed, even if you don't notice anything, because the medicine is working in your bloodstream to help control your diabetes.
Can Kombiglyze XR 5/1000 mg cause an allergic reaction, and what should I look for?
Yes, Kombiglyze XR can cause allergic reactions in some people. Watch for signs like rash, itching, swelling of your face, lips, or throat, difficulty breathing, or hives. If you experience any of these symptoms, stop taking the tablet and seek medical help immediately. Severe allergic reactions are rare but serious. Tell your doctor before starting if you've had allergies to saxagliptin (the main active ingredient) or any other medicines. If you're unsure whether your symptoms are an allergic reaction, contact your healthcare provider right away.
Are there any serious warning signs I should watch out for with Kombiglyze XR 5/1000 mg?
Watch for signs of pancreatitis (severe pain in your upper stomach, persistent vomiting, or yellowing of skin), severe allergic reactions (rash, swelling of face or throat, difficulty breathing), or signs of heart failure (unusual shortness of breath, sudden weight gain, swelling in legs). Stop taking Kombiglyze XR and seek immediate medical help if you experience any of these. Also report persistent joint pain or signs of infection to your doctor. Contact your doctor right away—do not wait for your next appointment.
Is it safe to drink alcohol while taking Kombiglyze XR 5/1000 mg?
Drinking alcohol while taking Kombiglyze XR can increase your risk of low blood sugar and may cause dizziness or weakness. Alcohol can also affect how your body processes the medicine. If you drink, keep it moderate and eat food with it. Always tell your doctor about your drinking habits so they can monitor you properly. Your doctor or pharmacist can give you specific guidance based on your individual health.
Which medicines should I avoid while using Kombiglyze XR 5/1000 mg?
Some medicines can interact with Kombiglyze XR and affect how well it works or increase your risk of side effects. Avoid taking other diabetes medicines without talking to your doctor first, as combining them may lower your blood sugar too much. Do not use gemfibrozil (a medicine for high cholesterol) with Kombiglyze XR. Certain blood pressure medicines and diuretics (water tablets) may also interact. Always tell your doctor and pharmacist about every medicine, supplement, and herbal product you're taking. Never stop or change any medicine without speaking to your doctor first.
Is Kombiglyze XR 5/1000 mg safe to take during pregnancy or while breastfeeding?
Kombiglyze XR is not recommended during pregnancy or breastfeeding. The medicine contains saxagliptin (a diabetes medication) and metformin, which may harm your developing baby or pass into breast milk. If you're pregnant, planning to become pregnant, or breastfeeding, tell your doctor immediately. Your doctor can discuss safer alternatives to manage your blood sugar during this time. Do not stop taking your current medicine without speaking to your healthcare provider first.
Are there any groups of people who should be extra careful when using Kombiglyze XR 5/1000 mg?
Yes, certain groups need extra care with Kombiglyze XR. People with a history of pancreatitis (inflammation of the pancreas), heart failure, or kidney problems should use this medicine cautiously. If you're pregnant, planning pregnancy, or breastfeeding, talk to your doctor first. People with a severe allergic reaction to any ingredient need to avoid it. Those taking other diabetes medicines may need dose adjustments. Older adults may require closer monitoring. Always tell your doctor about your full medical history before starting Kombiglyze XR to ensure it's safe for you.
Which strength of Kombiglyze XR 5/1000 mg is most commonly recommended?
Kombiglyze XR 5/1000 mg is the most commonly prescribed strength. This combination delivers 5 mg of saxagliptin (a medicine that helps your pancreas release insulin) and 1000 mg of metformin (a medicine that reduces sugar production in your liver). Your doctor will choose this or another strength based on your blood sugar levels, kidney function, and how you respond to treatment. The dose may be adjusted over time to work best for you.
What should I discuss with my doctor before starting Kombiglyze XR 5/1000 mg?
Before starting Kombiglyze XR 5/1000 mg, tell your doctor about any kidney or liver problems, heart disease, or history of pancreas inflammation (pancreatitis). Mention all other medicines you take, including supplements. Let them know if you're pregnant, breastfeeding, or planning pregnancy. Discuss any allergies to this medicine or similar diabetes drugs. Tell your doctor about recent surgery, severe infections, or if you drink alcohol regularly. They'll check if this medicine is right for you and adjust your dose if needed.
How do I safely dispose of leftover or out-of-date Kombiglyze XR 5/1000 mg?
Do not throw Kombiglyze XR tablets in the bin or down the toilet. Instead, take unused or out-of-date tablets to your local pharmacy, where staff will dispose of them safely following environmental and legal guidelines. If your pharmacy doesn't offer a disposal service, ask your doctor or local council for a designated medicine disposal facility in your area. Never keep expired medication at home.
How should I store Kombiglyze XR 5/1000 mg at home, and what happens if it expires?
Store Kombiglyze XR tablets in a cool, dry place away from direct sunlight and heat. Keep them in their original container with the lid tightly closed. Do not freeze. If your medicine expires, stop taking it and ask your pharmacist how to safely dispose of the expired tablets. Expired medicine may not work effectively and could potentially be harmful. Check the expiry date on your pack before each use, and replace your supply before it runs out.
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Flat 20% OFF
on your first purchase
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Maximum discount value $20
Only one coupon can be used at a time
Coupon code will be mailed on
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