Imat 400 mg Tablet
| Pack Size | Qty | Price Per Pill or Unit | Price | Offer | ||
|---|---|---|---|---|---|---|
| 10 Tablet/s | US$ 3.00 | US$ 30.0076%US$ 124.00 |
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| 30 Tablet/s | US$ 3.00 | US$ 90.0076%US$ 372.00 |
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| 60 Tablet/s | US$ 3.00 | US$ 180.0076%US$ 744.00 |
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| 90 Tablet/s | US$ 3.00 | US$ 270.0076%US$ 1,116.00 |
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| 120 Tablet/s | US$ 3.00 | US$ 360.0076%US$ 1,488.00 |
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Description
| SKU | 2762 |
|---|---|
| Generic For | Imatinib |
| Manufacturer | Intas Pharma, INDIA |
| Active Ingredient | Imatinib |
Imat 400 is a prescription cancer medicine that contains Imatinib 400mg as its active ingredient. It belongs to a class of drugs called tyrosine kinase inhibitors (TKIs), targeted therapies that block specific proteins that tell cancer cells to grow and multiply. Unlike traditional chemotherapy, this medicine targets cancer cells more precisely, which means it tends to cause fewer side effects compared to older treatment options.
Imat 400 tablets are manufactured to pharmaceutical-grade standards and are widely used by oncologists worldwide. If you are prescribed Imatinib, ReliableRxPharmacy offers genuine, quality-assured medicine at an affordable price with convenient home delivery.
Uses of Imat 400 mg
Imat Imatinib 400mg is prescribed for several types of cancer and certain rare conditions. Doctors use it for:
- Chronic Myeloid Leukemia (CML): CML is a type of blood cancer caused by an abnormal gene called BCR-ABL. The medicine blocks this gene, slowing or stopping the growth of leukemia cells. It is used in adults and children with newly diagnosed CML, as well as in patients where earlier treatments have stopped working.
- Gastrointestinal Stromal Tumors (GISTs): GISTs are rare tumor that form in the digestive system. Imat 400 is used both to treat GIST and to prevent it from coming back after surgery. It works by blocking the KIT protein that drives GIST cell growth.
- Acute Lymphoblastic Leukemia (Ph+ ALL): In patients whose leukemia cells carry the Philadelphia chromosome, Imat 400 can be used as part of the treatment plan.
- Myelodysplastic/Myeloproliferative Diseases: Imatinib 400mg is approved for certain blood disorders involving specific genetic abnormalities linked to the PDGFR gene.
- Aggressive Systemic Mastocytosis (ASM): A rare condition involving the abnormal growth of mast cells. The medicine helps control this disease in specific patient groups.
- Hypereosinophilic Syndrome (HES) and Chronic Eosinophilic Leukemia (CEL): These are rare conditions involving too many eosinophils (a type of white blood cell). Imatinib works by blocking abnormal proteins that drive the growth of these cells.
- Dermatofibrosarcoma Protuberans (DFSP): A rare type of skin tumor. Imat 400 is used when surgery is not possible or when the tumor recurs after surgery.
Always use Imat 400 only as directed by your oncologist or treating doctor. Self-medication with cancer drugs is dangerous and should be strictly avoided.
How Does Imat 400 Work?
Imat 400 works through targeted molecular therapy. It blocks a specific enzyme, tyrosine kinase, found in abnormal cancer cells. Tyrosine kinase acts like an "on switch" that tells cancer cells to grow. By turning off this switch, Imatinib 400mg slows down cancer cell growth and eventually causes the cancer cells to die.
In CML, the BCR-ABL tyrosine kinase is the main target. In GIST, the KIT and PDGFRA proteins are the primary targets. This targeted approach means Imat tab can attack cancer cells while having a much smaller effect on healthy normal cells, making it a major advancement in cancer treatment.
Imat 400 Dosage and Administration
The dose of Imat your doctor prescribes will depend on your specific condition, body weight, and how well you are responding to treatment. Below is a general overview:
- CML in adults: The usual starting dose is 400mg once daily. In some cases, the dose may be increased to 600mg or 800mg per day if needed.
- CML in children: Dosing is based on body surface area (mg/m²). The doctor will calculate the exact dose.
- GIST (after surgery): Typically 400mg per day for up to three years.
- GIST (unresectable or metastatic): Usually 400mg per day; may be increased to 800mg if needed.
- Ph+ ALL: 600mg/day is commonly used.
How to take: Swallow the tablet whole with a large glass of water. Take it with a meal to reduce stomach upset. Do not crush, chew, or break the tablet unless your doctor advises otherwise. If you forget to take your dose, take it as soon as you remember, unless it is almost time for your next dose. Never double up to make up for a missed dose. Do not take more than the prescribed amount. If you suspect an overdose, seek emergency medical help immediately.
Imat 400 Precautions and Warnings
Imat 400 is not right for everyone. Do not take this medicine if you are allergic to Imatinib or any of the tablet ingredients. Before starting the medicine, make sure your doctor is aware of your full medical history if you have/had liver or kidney disease, heart conditions, you drink regularly, are pregnant or a breastfeeding mother. In children and adolescents, Imat can affect bone growth, so regular monitoring is important if your child is prescribed this medicine.
Always consult a qualified oncologist before starting, changing, or stopping treatment with this medicine.
Drug Interactions - Imat 400 can interact with several other medicines. Always tell your doctor and pharmacist about everything you are taking, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. Important interactions include:
- CYP3A4 inhibitors (such as ketoconazole, itraconazole, erythromycin, clarithromycin): These can increase the level of Imatinib in your blood, raising the risk of side effects.
- CYP3A4 inducers (such as rifampicin, carbamazepine, phenytoin, St. John's Wort): These can reduce Imatinib levels, making it less effective.
- Warfarin and other blood thinners: Imat 400 may affect how these medicines work. If you need a blood thinner, your doctor may prefer to use low-molecular-weight heparin instead.
- Simvastatin: Imatinib can increase simvastatin levels in the blood, raising the risk of muscle problems.
- Paracetamol (acetaminophen): High doses may increase liver stress when combined with Imatinib.
Never start or stop any medicine while on Imat 400 without checking with your healthcare provider.
Driving and using machines: Some patients experience dizziness or blurred vision while on Imatinib. Be cautious when driving or operating heavy machinery.
Imat 400 Side Effects
Like all medicines, Imat 400 can cause side effects. Most side effects are mild to moderate and improve as your body adjusts to the treatment. However, some can be serious. Common side effects include nausea, vomiting, constipation or diarrhea, swelling in the face, hands, or feet, muscle cramps or pain, fatigue and tiredness, headache, skin rashes, and stomach pain.
Less common side effects:
- Low blood cell counts (can increase risk of infection, bleeding, or anemia)
- Liver problems, symptoms include yellowing of the skin or eyes, dark urine, or severe stomach pain.
- Severe fluid retention, unusual weight gain, shortness of breath, or swelling around the lungs or heart
- Heart problems in some patients
- Severe skin reactions (rare)
Tell your doctor right away if you notice any unusual or severe symptoms. Do not stop taking Imat 400 without first talking to your doctor, even if you feel unwell.
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