Activelle (1+0.5)mg

Estradiol - Norethindrone Acetat

Only %1 left

Out of stock

Out Of Stock

This product is temporarily unavailable due to supply issues. Please leave your e-mail address so we can update you as soon as the product is in stock:

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Description

SKU	386
Generic For	Activelle
Strength	(1+0.5)mg
Manufacturer	Novo - Nordisk, Denmark
Active Ingredient	Estradiol - Norethindrone Acetat

Product Description

Activelle (1+0.5)mg for Women'S Health — Order Online

Name: Activelle (1+0.5)mg
Brand: Activelle
SKU: 386
Availability: OutOfStock

Description of the drug

Estradiol and Norethindrone Acetate are the main active pharmaceutical ingredients present in Activelle 1 mg + 0.5 mg tablet. The medicine is a combination of two female hormones Estrogen and progestin produced by the ovaries. It is a hormone replacement therapy, used by a women that help in reducing the symptoms of menopause such as hot flashes and vaginal dryness, these symptoms occur due to the less estrogen produced by the body. The progestin present in this medicine, helps to reduce the risk of cancer of the uterus, which can be caused by using estrogen alone. Each tablet of Activelle contains 1 mg of Estradiol and 0.5 mg of Norethindrone Acetate.

Indications and Usage

The combination drug is mostly used as a hormone replacement treatment in menopausal women, who still have their uterus. Estradiol is an Estrogen and Norethindrone is a Progestin, both are female sex hormones. This drug is indicated to be used by the women in order to treat hot flushes, who are experiencing menopause. This medicine is also used to prevent osteoporosis, replace estrogen in women with ovarian failure, or as part of a cancer treatment regimen. It works by replacing a natural progestin and estrogen in women who can no longer produce enough of these hormones.

Dosage and Administration

-Recommended dose:

The dose may vary according to the patient condition therefore it is advised to take this medicament as per your doctor’s direction.

-Method of Administration:

Activelle is available in the form of a tablet taken orally by mouth, usually once a day with a glass of water. Do not break, crushed, or chew the tablet, it will cause you a bitter taste.

-Missed dose

If you miss one or more doses; take the next dose on time. If not taken on time it will increase the risk of becoming pregnant. It is advised to talk to your doctor and do not take more than your doctor is prescribed.

-Overdose:

The overdose of any drug can cause severe effects. The overdose symptoms may include extreme drowsiness, agitation, aggression, shallow breathing, weakness, fainting, headache, vomiting and many other allergic symptoms. In the case of an overdose, you should immediately contact your doctor.

Forms and Strengths

The drug Estradiol and Norethindrone Acetate is available on our website in the following strength and forms under the brand name of:

Activelle (1 mg+ 0.5 mg) Tablet

Contraindications

This drug should not be used in patients with known or suspected hypersensitivity to any of the ingredients present in the formulation
This drug should not be used in pregnant women. It may harm the unborn baby
This drug should not be used in lactating women, using this medicine while breastfeeding is harmful to the new born baby as this drug may pass through the breast milk.
Do not use this medication if the patient has had a cancer, such as breast cancer or a cancer of the womb lining or ovary
This drug should not be used in women, who are suffering from unexplained abnormal vaginal bleeding
Do not use this medication if you are having the habit of smoking and are older than 35 years of age.
This medicine should not be used in those patients, who is having the highest risk of venous or arterial thrombosis diseases.
This drug should not be given to those women who are suffering from uncontrolled high blood pressure, a heart disease, a blood clotting disorder
This drug should not be used in those women, who have had their uterus removed because they do not need the progestin and therefore should not use this combination medication
This medicament is contraindicated for the male patients

Warnings and precautions

Using estrogen alone may increase the chances of getting cancer of the uterus. If you experienced any vaginal bleeding, which is undiagonosed. Vaginal bleeding after menopause may be a sign of cancer, therefore in this case contact your doctor immediately.
If a patient is suffering from any kind of liver and kidney problem, including dialysis treatment, mental disorder such as depression, this drug is harmful in these conditions, therefore, it is advised to consult your doctor and let him know about your medical history prior taking this drug.
If the patient is suffering from Thrombosis. Thrombosis is the formation of a blood clot in a blood vessel such as deep venous thrombosis or the lungs such as pulmonary embolism. In these conditions this drug should not be consumed without consulting the doctor. It is advised to take this drug only after consulting and prescription of the doctor.
This drug is not suitable, if the patient is suffering from jaundice. Consult your doctor before taking this medicament.
This drug is not suitable for those patients having a heart problem like angina, high blood pressure, or a heart attack. Consult your doctor first, if you have any kind of heart problem before taking this medication.
This drug is not suitable for those patients who are suffering from asthma, diabetes, migraine or an epilepsy problem. In these conditions, consult your doctor before taking this medicament.
This drug is not suitable for those patients, if they ever had bleeding in the brain, stroke, heart attack, or other serious blood vessel problems. In this case, consult your doctor before taking this medicament.
This drug is not suitable for those women who have a history of breast nodules, fibrocystic disease of the breast, an abnormal breast x-ray or mammogram, or irregular or scanty menstrual periods. Consult your doctor before taking this medicament.
If the patient has reported any kind of allergic reaction in the past with any kind of food, dyes, or medicines, then consult your doctor before applying this medicament.
This drug is not suitable, if the patient is having any blood problem.
This drug is not suitable for those patients, having surgery or will be confined to a bed or a chair for a long period of time. Consult your doctor regarding the same prior taking this medicine.
This drug is not suitable for those patients, suffering from tuberculosis. Consult your doctor, let him know about your medical problem before taking this medicament.
This drug is not suitable for those patients, who are overweight, having a high cholesterol level or triglycerides, or having a fluid retention or a swelling problem. Before taking this drug, consult your doctor regarding your medical problem.
This drug is not suitable for those women, who are suffering from any kind of cancer. It is advised to tell your doctor about your disease before taking this medicament.
If the patient has reported any kind of allergic reaction in the past with any kind of food, dyes, or medicines, then consult your doctor before applying this medicament.
Use this drug with caution in elderly patients, older adults may be more sensitive to the side effects of this drug.
Before buying Activelle tablets (1 mg + 0.5 mg) online, it is necessary to do a thorough research on its ingredients.

Side effects

Tell your doctor if you have any side effects that bothers you or does not go away.

Some common side effects that can occur:

Changes in menstrual bleeding, eg., irregular bleeding or sometimes stopping of bleeding.
Mood changes, including depression.
Decreased sex drive
Headache
Nausea.
Acne.
Breast tenderness.
Weight gain.
Rash or hives.
Ectopic pregnancy

Some rare side effect can occur which will be serious:

Fever
Shortness of breath
Blurred vision
Jaundice
Mood swings
Vaginal discharge
Weight gain
Hair loss
Cysts on the ovaries
Painful menstrual cycle
Acne
Less sexual desire
Migraine
Signs of blood clot
Irritation or itching of the skin in or around the vagina.
Breasts become swollen, tender or painful
Burning off your skin

Drug Interactions

These are the drugs that can alter the pharmacological effect of Estradiol:

Abiraterone acetate
Amiodarone
Anastrozole
Aripiprazole
Ascorbic acid (vitamin C)
Atorvastatin
"Azole" antifungals (e.g., ketoconazole, itraconazole, vorionazole)
Barbiturates (e.g., phenobarbital)
Bosentan
Blood pressure-lowering medications (e.g., propranolol, enalapril, diltiazem)
Carbamazepine
Carvedilol
Celecoxib
Cobicistat
Corticosteroids (e.g., hydrocortisone, prednisolone, prednisone)
Crizotinib
Cyclosporine
Cyproterone
Dabrafenib
Deferasirox
Dehydroepiandosterone
Dexamethasone
Diabetes medications (e.g., chlorpropamide, glipizide, glyburide, insulin, metformin, nateglinide, rosiglitazone, saxagliptin)
Dipyridamole
Doxorubicin
Dronedarone
Efavirenz
Etravirine
Grapefruit juice
HIV protease inhibitors (e.g., lopinavir, ritonavir, saquinavir)
Lenalidomide
Mefloquine
Mitotane
Modafinil
Nefazodone
Pilotinib
Phenytoin
Primidone
Progesterone
Propranolol
Quinidine
Quinine
Rifabutin
Rifampin
Ropinirole
St. John's wort
Somatropin
Sunitinib
Tacrolimus
Tamoxifen
Telaprevir
Temazepam
Tenofovir
Teriflunomide

Thalidomide

Theophyllines (e.g., aminophylline, oxtriphylline, theophylline)

Thyroid medications (e.g., levothyroxine, liothyronine)
Tizanidine
Tocilizumab
Trazodone
Ursodiol
Verapamil
Vinblastine
Warfarin

Ask your doctor and get the full list of drugs that may increase the possibility of drug interactions or interfere with the effectiveness of Activelle (1mg + 0.5 mg) tablet.

Ingredients

Activelletablet comprises of an active pharmaceutical ingredient called Estradiol and Norethindrone Acetate. It belongs to the class of medication known as estrogen replacement therapy. It works by replacing natural progestin and estrogen in women who are unable and no longer make or produce enough of these hormones. This is how Activelle works and treats moderate to severe symptoms of menopause such as hot flashes, dryness, itching, or burning in or around the vagina. It is also used to prevent osteoporosis (weakened bones) in certain women after menopause.

Storage information

Activelle (1 mg + 0.5 mg) tablets should be stored in a safe place that is away from heat and moisture. Do not refrigerate. Keep it out of the reach of children and pets. Do not keep the tablets out in open.

Manufacturer

Activelle (1 mg + 0.5 mg) Tablet is manufactured by Novo - Nordisk, Denmark. It is a multinational pharmaceutical company. It develops and manufactures the pharmaceutical products. You can easily buy Activelle tablets (1 mg + 0.5 mg) online from our website and we will deliver this product at your doorsteps.

FAQ

What is Activelle (1+0.5)mg used for?

Activelle (1+0.5)mg is used to treat moderate to severe hot flushes and night sweats caused by menopause. It contains estradiol (a female hormone) and norethindrone acetate (a synthetic progestin [hormone-like medicine]) that work together to relieve these symptoms. The combination also helps prevent bone loss that can occur after menopause. Your doctor will determine if this medicine is right for you based on your individual health needs and medical history.

Who is Activelle (1+0.5)mg meant for, and is it right for me?

Activelle is a hormone replacement therapy (HRT) tablet for women going through menopause. It contains estradiol and norethindrone acetate to relieve hot flushes, night sweats, and vaginal dryness. Your doctor prescribes it based on your symptoms, age, and medical history. It's not suitable if you've had breast cancer, blood clots, or certain heart conditions. Only your doctor can decide if Activelle is right for you—discuss your menopause symptoms and health background with them before starting.

What should I do if I forget to take a dose of Activelle (1+0.5)mg?

If you forget to take a dose of Activelle, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Never take two doses at once to make up for a missed one. If you're unsure about what to do, contact your doctor or pharmacist for guidance. Consistency with your routine helps the medicine work effectively.

Can I stop using Activelle (1+0.5)mg once I start feeling better?

Do not stop taking Activelle without speaking to your doctor first, even if you feel better. Hormone replacement therapy (a medicine that replaces hormones your body no longer makes during menopause) works best when taken regularly as prescribed. Stopping suddenly can cause your symptoms to return and may affect your treatment plan. Your doctor will advise you when and how to stop taking this medicine safely, which may involve gradually reducing your dose.

How quickly will I notice Activelle (1+0.5)mg working?

Activelle begins working immediately after you take your first tablet, but you won't notice symptom relief right away. Most women experience improvements in hot flushes, night sweats, and mood changes within 2–4 weeks of consistent use. Some symptoms like vaginal dryness may take 6–12 weeks to improve. Results vary between individuals. Continue taking your tablet daily as prescribed, and consult your doctor if you don't see improvement after 8 weeks.

How will I know if Activelle (1+0.5)mg is working for me?

You'll notice Activelle is working when your menopausal symptoms improve. Most women see relief from hot flushes and night sweats within 2–4 weeks, though some take 8–12 weeks for full benefit. You may also notice better sleep, less mood changes, and improved vaginal dryness. Keep a symptom diary to track improvements. If you see no changes after 3 months, or if symptoms worsen, talk to your doctor—they may adjust your dose or try a different approach.

What are the common side effects of Activelle (1+0.5)mg, and should I be worried?

Most users experience mild side effects that often improve within a few weeks. Common ones include breast tenderness, nausea, headaches, and slight bleeding changes. Some people notice mood changes or bloating. These are normal responses as your body adjusts to the hormones. However, stop taking Activelle and contact your doctor immediately if you experience chest pain, severe headaches, leg swelling, or vision changes—these need urgent medical attention. Report any persistent side effects to your doctor; they can adjust your dose or suggest alternatives if needed.

Can Activelle (1+0.5)mg cause an allergic reaction, and what should I look for?

Yes, allergic reactions to Activelle are possible, though uncommon. Watch for signs like rash, itching, swelling of your face or throat, difficulty breathing, or hives. If you experience any of these symptoms, stop taking the tablet and seek medical help immediately. You may also be allergic to one of the inactive ingredients in the tablet. Tell your doctor about any known allergies before starting Activelle, especially to estradiol or norethindrone acetate. Severe allergic reactions are rare but require emergency care.

Is it safe to drink alcohol while taking Activelle (1+0.5)mg?

Moderate alcohol consumption is generally safe while taking Activelle. However, drinking heavily or regularly may increase your risk of blood clots and stroke, which are already slightly elevated with this hormone replacement therapy (a medicine containing female hormones to manage menopause symptoms). Limit alcohol intake and speak with your doctor if you drink regularly. If you experience unusual leg pain, chest discomfort, or shortness of breath, seek medical help immediately.

Are there any foods or drinks I should avoid while on Activelle (1+0.5)mg?

There are no specific foods or drinks you need to avoid while taking Activelle. You can eat and drink normally. However, avoid excessive alcohol, as it may increase your risk of blood clots and breast cancer when combined with hormone therapy. If you have concerns about your diet or specific foods, discuss them with your doctor or pharmacist.

Are there any groups of people who should be extra careful when using Activelle (1+0.5)mg?

Certain groups need extra caution with Activelle. You should be careful if you have a history of blood clots, stroke, or heart disease. Tell your doctor if you have liver problems, kidney disease, migraines with aura (visual disturbances before headache), or uncontrolled high blood pressure. Women over 60 starting hormone therapy, those who smoke, or who are overweight need closer monitoring. If you have a family history of breast cancer or blood clots, discuss this with your doctor before taking Activelle. Always inform your healthcare provider of your complete medical history.

Can older adults or children use Activelle (1+0.5)mg safely?

Activelle is not suitable for children—it contains hormones designed only for adult women. Older adults can use Activelle if a doctor prescribes it, as age alone doesn't prevent safe use. However, your doctor will assess your individual health, medical history, and any conditions that might make this medicine unsuitable. Always follow your doctor's guidance about whether Activelle is right for you.

How does Activelle (1+0.5)mg compare to other treatments used for the same condition?

Activelle combines two hormones—estradiol and norethindrone acetate—to relieve menopause symptoms and protect bone health. Other treatments include estrogen-only tablets, different hormone combinations, vaginal creams, or non-hormone options like antidepressants. Your choice depends on your symptoms, medical history, and how your body responds. Some women prefer combined hormones like Activelle because they address hot flushes, night sweats, and mood changes while reducing endometrial [womb lining] cancer risk. Your doctor will recommend the best option for you based on your individual needs and health profile.

What are my options if Activelle (1+0.5)mg does not agree with me?

If Activelle doesn't agree with you, talk to your doctor before making any changes. Your doctor may suggest adjusting your dose, taking it at a different time of day, or switching to a different hormone replacement therapy [medicine that replaces hormones your body no longer makes]. Some women find their side effects improve after a few weeks as their body adjusts. Your doctor might also recommend trying a different estradiol-norethindrone acetat formulation or an entirely different type of hormone replacement. Never stop taking Activelle without medical guidance, as this could cause withdrawal symptoms. Your doctor will help find the option that works best for your body.

Can I order Activelle (1+0.5)mg from ReliableRxPharmacy, and do I need a prescription?

Yes, you can order Activelle (1+0.5)mg from ReliableRxPharmacy. You'll need a valid prescription from your doctor to purchase this medication, as it's a hormone replacement therapy (HRT) tablet containing estradiol and norethindrone acetate. We source all our medicines from authorised distributors of manufacturers to ensure quality and safety. To place your order, submit your prescription during checkout, and our team will verify it before processing your request.

How quickly can I receive Activelle (1+0.5)mg if I order from ReliableRxPharmacy?

When you order Activelle from ReliableRxPharmacy, standard delivery takes 20–30 business days. This timeframe applies to orders shipped internationally and to North America. Your order is sourced from authorised distributors of the manufacturer and processed through our secure shipping system. Delivery times may vary slightly depending on customs clearance and your location. We recommend placing your order well in advance of when you'll need your medication to ensure uninterrupted supply.

Reviews