Pangraf is available for oral administration as tablets containing 0.5 mg tacrolimus. It is a prescription medicine used with other pharmaceutical agents to help prevent organ rejection in individuals who have had a heart, kidney, or liver transplant. Tacrolimus prolongs the survival and transplanted graft of the heart, kidney, liver, bone marrow, lung, trachea, cornea, limb, pancreas, and skin. The medicine is not for use with medicines called cyclosporines. It is unknown whether the medicine is safe and effective when used with sirolimus in patients who have undergone a heart or liver transplant. Also, the immunosuppressive drug may not be safe and effective in children who have heart or kidney transplants.

Take Pangraf tablets exactly as your doctor prescribes them. Your doctor will tell you how many tablets and for what time you need them. Your doctor may make dose adjustments as per your condition. Do not discontinue treatment without your doctor’s approval. Take the tablet before consuming food. You may be advised to take Tacrolimus tablets twice daily, 12 hours apart. Do not eat grapefruit or drink grapefruit juice while taking the medication. Taking too much medicine can cause serious complications, so if you take too much of this immunosuppressive drug, call your doctor straight away.

Do not take Pangraf 0.5 mg if you are allergic to Tacrolimus, and the medicine is effective at preventing and treating organ transplant rejection. Before you take Tacrolimus tablets, tell your doctor if you plan to receive any live vaccines, have had heart, liver disease, kidney disease, or plan to become pregnant.

Pangraf 0.5 mg can cause serious side effects including,

• High blood sugar- call your doctor straight away if you develop symptoms such as drowsiness, frequent urination, confusion, loss of appetite, fruity smell on your breath, nausea, vomiting, stomach pain, blurred vision, increased thirst or hunger, blurred vision, drowsiness, loss of appetite, and frequent urination.
• High blood pressure- It is important to monitor your blood pressure while receiving Pangraf 0.5 mg.
• Nervous system problems- Call your doctor straight away if you get symptoms such as muscle tremors, seizures, coma, confusion, vision changes, numbness and tingling, and headache.
• Heart problems- Inform your doctor straight away if you get symptoms of heart disease while taking Pangraf tablets. These include light-headedness, fainting, chest pain, shortness of breath.
• Kidney problems- Your doctor can perform certain tests to check your kidney function during the treatment.

The most common side effects in people receiving kidney transplants are infection, stomach pain, nausea, diarrhea, constipation, trouble sleeping, kidney problems, tremors, pain, weakness, high levels of potassium in your blood, high levels of fat in your blood, low blood cell count, pain, low levels of phosphate, high blood pressure, swelling of the hands, legs, and ankles, and anemia.

Let your doctor know if you have any side effects that bother you and do not go away.