Natrise 30 mg effectively treats low levels of sodium in the blood. It contains the active ingredient Tolvaptan, which treats low sodium levels in the blood due to conditions such as cirrhosis, heart failure, and syndrome of inappropriate antidiuretic hormone (SIADH). Tolvaptan blocks the effect of the hormone vasopressin in the body, which increases urine production, reduces water in the blood, and improves blood sodium levels.

Natrise is taken orally once daily with or without food for 30 days. At the beginning of the treatment, you will be given Natrise at a regularly scheduled time in the hospital. If you are told to take Natrise at home after being discharged from the hospital, you must take it daily at the same time. Carefully follow the directions given by your doctor. Do not take medicine more or less than prescribed. Your doctor will usually start your treatment with a low dose and gradually increase your dose. Speak to him about what precautions you should take after you stop taking Natrise. You will probably need to limit your fluid intake, and your doctor will monitor you carefully during this time.

Do not administer to patients requiring urgent intervention to raise serum sodium accurately. It should not be taken by patients who cannot sense or respond appropriately to thirst. Do not administer in anuric patients, as no benefit is expected. Natrise should be used with caution in patients with diabetes. Tolvaptan can cause the level of sodium to increase rapidly, which may cause osmotic demyelination syndrome (ODS).

Inform your doctor if you:

  — Drink a lot of alcohol, have malnutrition, or have liver problems.

  — Taking certain antifungals such as ketoconazole, clarithromycin, itraconazole, and certain medications for HIV (nelfinavir, ritonavir, saquinavir);

  — Taking vitamins and nutritional supplements.

  — Have had a high potassium level in your bloodstream.

Using Natrise 30 mg may cause a few common side effects. The most common side effects are dry mouth, constipation, thirst, polyuria, asthenia, and hyperglycaemia. These side effects do not require medical help and disappear as your body adjusts to the medicine. Speak to your doctor if they persist or if you are worried about them. Before using this medicine, let your doctor know if you have any problems with your liver or kidney. During the treatment, he will closely monitor the sodium levels.