| Pack Size | Qty | Price Per Pill or Unit | Price | Offer | ||
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| 30 Tablet/s | US$ 1.15 | US$ 34.6217%US$ 41.60 |
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| 60 Tablet/s | US$ 1.13 | US$ 67.9418%US$ 83.18 |
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| 90 + 10 Tablet/s Extra | US$ 1.00 | US$ 99.9720%US$ 124.77 |
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Description
| SKU | 1308 |
|---|---|
| Generic For | Augmentin 375 |
| Strength | 375 |
| Manufacturer | GSK, India |
| Active Ingredient | Amoxicillin Clavulanic Acid |
Augmentin 375 for Bacterial Infections — Order OnlineÂ
Augmentin 375 is a broad-spectrum antibiotic combination tablet widely used to treat bacterial infections across a range of body systems. It combines two powerful antimicrobial agents to treat infections that may be resistant to standard antibiotics effectively.
What is Augmentin 375?
Augmentin 375 is a film-coated antibiotic tablet containing a fixed-dose combination of amoxicillin 250mg and clavulanic acid 125mg (combined strength: 375mg). Amoxicillin is a broad-spectrum penicillin-type antibiotic, while clavulanic acid is a beta-lactamase inhibitor that prevents bacterial beta-lactamases from inactivating the antibiotic. Together, they form a synergistic partnership that extends the range of infections treatable with a penicillin-type antibiotic.
Manufacturer: Manufactured by GSK, India, a globally recognised pharmaceutical manufacturer.
Active Ingredients & how do they work?
Amoxicillin (250mg): Amoxicillin works by interfering with bacterial cell wall synthesis. Bacteria depend on intact cell walls for structural integrity and survival. By inhibiting key enzymes (transpeptidases/penicillin-binding proteins) involved in cell wall construction, amoxicillin causes the bacterial cell wall to break down, ultimately killing the bacteria.
Clavulanic acid (125mg): Many bacteria produce enzymes called beta-lactamases that destroy standard penicillins like amoxicillin. Clavulanic acid is a beta-lactamase inhibitor, it binds to and inactivates these enzymes, protecting amoxicillin from degradation. This combination restores the antibiotic's effectiveness against resistant bacterial strains.
Clinical uses
Augmentin 375 is indicated for the treatment of:
   -  Respiratory tract infections — bronchitis, pneumonia, tonsillitis
   -  Ear, nose and throat infections — sinusitis, middle ear infections (otitis media)
   -  Urinary tract infections (UTIs) — cystitis, pyelonephritis
   -  Skin and soft tissue infections — cellulitis, wound infections
   -  Abdominal and intra-abdominal infections
   -  Dental infections — dental abscesses, periodontitis
   -  Bone and joint infections (selected cases)
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Key benefits
   -  Dual-action formula defeats both standard and beta-lactamase-producing resistant bacteria.
   -  Broad-spectrum coverage against a wide range of gram-positive and gram-negative organisms
   -  Well-established safety profile backed by extensive global clinical use
   -  Available in multiple strength options (375mg, 500/125mg, 875/125mg) to suit infection severity
   -  Effective against a wide variety of common infections, reducing the need for IV antibiotics in mild-to-moderate cases
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Dosage, administration, & storage of amoxicillin/clavulanic acid
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Dosage: For adults and children over 12 years (or weighing over 40kg), the standard dose is 1 375mg tablet three times daily (every 8 hours) for up to 2 weeks. For dental infections, the usual course is five days at the same frequency. Severe infections may warrant higher-strength formulations.
Administration: Take Augmentin 375 at the start of a meal to reduce the risk of gastrointestinal side effects. Complete the entire prescribed course even if you feel better before it ends, to prevent recurrence and antibiotic resistance.
Storage: Store in a cool, dry place below 25°C. Keep away from direct sunlight and out of reach of children. Do not use after the expiry date on the packaging.
Related strengths and products: In addition to 500 mg, Augmentin 375mg, Augmentin 625 mg Duo, Augmentin 1g Duo, and Augmentin Dry Syrup 30ml are available, depending on the type and severity of the infection.
Precautions, warnings & drug interactions with amoxicillin/clavulanic acid
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Do not take Augmentin 375 if you are allergic to penicillins, cephalosporins, or any component of the tablet. Inform your doctor if you have ever experienced liver problems while taking antibiotics, have glandular fever, kidney disease, or are pregnant or breastfeeding.
Important drug interactions:
   -  Anticoagulants (warfarin) — Augmentin may enhance the blood-thinning effect; closer INR monitoring is required
   -  Methotrexate — amoxicillin can reduce methotrexate clearance, increasing its toxicity
   -  Other antibiotics — concurrent use may enhance or reduce effectiveness; always inform your doctor
   -  Allopurinol (gout medication) — increased risk of skin rashes
   -  Oral contraceptives — may reduce effectiveness; use additional contraceptive measures during the treatment course.
Side effects associated with amoxicillin/clavulanic acid
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Most patients tolerate Augmentin 375 well. The most frequently reported side effects of antibiotics are gastrointestinal. Common side effects include diarrhoea, nausea or vomiting, indigestion or stomach discomfort, headache, dizziness, and tooth discolouration (usually resolved by brushing). Less common side effects include skin rash or itching (may indicate penicillin allergy — seek medical advice), hyperactivity or mild CNS effects, liver enzyme elevations (rare), and severe hypersensitivity reactions including anaphylaxis (seek emergency care immediately)
Trusted place to buy Amoxicillin online
Buying this medicine online can be really beneficial, especially when you choose ReliableRxPharmacy. The website offers notable advantages, including cost savings compared to branded antibiotics at local pharmacies and the convenience of quick, hassle-free ordering. Customers benefit from discreet packaging, access to various strengths in one place, reliable quality standards, secure transactions, verified reviews, and attractive discounts on initial purchases.
How does Augmentin 375 work in the body?
Augmentin 375 contains two active ingredients that work together to fight bacterial infections. Amoxicillin kills bacteria by breaking down their cell walls, stopping them from surviving. Clavulanic acid protects the amoxicillin by blocking enzymes (proteins) that some bacteria produce to resist the antibiotic. Together, they're more effective at eliminating infections that amoxicillin alone might not control. This combination helps your body's immune system clear the infection more quickly.
Can I stop using Augmentin 375 once I start feeling better?
No, you should not stop taking Augmentin 375 just because you feel better. You must complete the full course prescribed by your doctor, even if your symptoms disappear. Stopping early allows bacteria to survive and develop resistance to the antibiotic, making the infection harder to treat later. This resistance can spread to others too. Always finish all tablets as directed, unless your doctor tells you to stop. If you have concerns about your treatment, contact your doctor before making any changes.
How much Augmentin 375 should I take, and how often?
Your doctor will prescribe the exact dose and frequency based on your infection type and severity. Typically, Augmentin 375 is taken three times daily with or without food. Swallow the tablet whole with water. Never adjust your dose without consulting your doctor, even if you feel better. Complete the full course as prescribed to prevent antibiotic resistance. Always follow the instructions on your prescription label or pharmacy label for your specific dosing schedule.
What things can affect how well Augmentin 375 works?
Several factors can reduce how well Augmentin 375 works. Taking it with food can lower absorption (how your body takes it in), so take it on an empty stomach or with minimal food. Alcohol may reduce effectiveness and increase side effects. If you have severe kidney problems, your body cannot clear the medicine properly, reducing its power. Missing doses or not finishing the full course weakens its ability to kill bacteria. Taking it with certain other medicines can interfere with its work. Always complete your full prescription as directed, even if you feel better.
How quickly will I notice Augmentin 375 working?
You'll typically start noticing Augmentin 375 working within 2–3 days of starting treatment. Many people feel better after this time as the antibiotic (a medicine that kills bacteria) reduces your infection. However, you should take the full course your doctor prescribed, even if you feel better earlier. Completing the entire treatment prevents the infection from returning and stops bacteria developing resistance (becoming harder to treat).
Are there any serious warning signs I should watch out for with Augmentin 375?
Stop taking Augmentin 375 and seek immediate medical help if you experience severe allergic reactions (difficulty breathing, swelling of face or throat), severe diarrhoea with blood or mucus, severe skin rash, yellowing of skin or eyes, unusual bruising or bleeding, or severe abdominal pain. These can indicate serious conditions requiring urgent care. If you notice any concerning symptoms while taking this medicine, contact your doctor or go to the nearest emergency department right away.
Is it safe to use Augmentin 375 for a long period of time?
Long-term use of Augmentin 375 requires your doctor's guidance. While the medicine is generally well-tolerated, extended use increases the risk of side effects like yeast infections or digestive problems. Your doctor will monitor your condition and decide if continued treatment is appropriate for your specific infection. Never stop or change your dosage without consulting your doctor, even if you feel better. Some infections genuinely require longer courses, but only your healthcare provider can determine what's safe for you.
Are there any foods or drinks I should avoid while on Augmentin 375?
You can eat and drink normally while taking Augmentin 375. There are no foods or drinks you must avoid. However, taking your tablet with food may help reduce stomach upset if you experience it. Avoid alcohol while on this antibiotic, as it may increase nausea and dizziness. If you have a milk allergy, tell your doctor before starting treatment. Continue taking your doses at the scheduled times, with or without meals, unless your doctor advises otherwise.
Which medicines should I avoid while using Augmentin 375?
Some medicines can interact with Augmentin 375. Avoid taking methotrexate (a medicine for cancer and autoimmune conditions) as it may increase toxic effects. Tell your doctor if you take blood thinners like warfarin, as Augmentin may increase bleeding risk. Probenecid (used for gout) can reduce how your body clears this antibiotic. Always inform your doctor about all medicines, vitamins, and supplements you take before starting Augmentin 375. Do not stop or change any medicine without speaking to your doctor first.
Do I need a different dose of Augmentin 375 if I have kidney or liver problems?
Your dose of Augmentin 375 may need adjustment if you have kidney or liver problems. Amoxicillin (an antibiotic) and clavulanic acid (a substance that helps the antibiotic work) are processed by your kidneys and liver. If these organs don't work properly, the medicine can build up in your body to unsafe levels. Your doctor will assess your kidney and liver function and may reduce your dose or change how often you take it. Do not adjust your dose yourself—always tell your doctor about any kidney or liver issues before taking Augmentin 375.
Is Augmentin 375 safe to take during pregnancy or while breastfeeding?
Augmentin 375 is generally considered safe during pregnancy and breastfeeding, but you must consult your doctor before taking it. Both amoxicillin and clavulanic acid pass into breast milk in small amounts, though this is unlikely to harm your baby. Your doctor will weigh the benefits of treating your infection against any potential risks and may recommend an alternative if needed. Never start or stop this medicine without medical advice during pregnancy or while breastfeeding.
What should I discuss with my doctor before starting Augmentin 375?
Before starting Augmentin 375, tell your doctor if you have a penicillin or cephalosporin allergy, liver or kidney problems, or a history of diarrhoea caused by antibiotics. Mention any other medicines you're taking, including birth control pills, as Augmentin may reduce their effectiveness. Let your doctor know if you're pregnant or breastfeeding. Also discuss any previous allergic reactions to medicines. Your doctor needs this information to ensure Augmentin 375 is safe for you.
Which strength of Augmentin 375 is most commonly recommended?
Augmentin 375 contains a fixed combination of 250mg amoxicillin (an antibiotic) and 125mg clavulanic acid (a substance that prevents bacteria resisting the antibiotic). This 250/125mg strength is the most commonly prescribed form for adults with mild to moderate bacterial infections. Your doctor will choose this strength based on the type and severity of your infection and your health status. Always take the exact strength your doctor prescribes.
How should I store Augmentin 375 at home, and what happens if it expires?
Store your Augmentin 375 tablets in a cool, dry place away from direct sunlight and heat. Keep them in their original container with the lid tightly closed. Do not freeze them. If expired Augmentin is used, it may no longer work effectively against your infection, and the active ingredients can break down over time. Always check the expiry date before taking a dose, and dispose of expired tablets safely at a pharmacy or following local medicine disposal guidelines.
How can I get the best price on Augmentin 375 at ReliableRxPharmacy?
ReliableRxPharmacy sources Augmentin 375 from authorised distributors of manufacturers, allowing us to offer competitive pricing. To get the best price, compare our current rates with other licensed pharmacies, check for available discounts or bulk-order savings on our site, and sign up for our newsletter for exclusive offers. We guarantee quality medicines at transparent prices, so you know exactly what you're paying. Contact our customer service team if you have questions about pricing or payment options.
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