Description of the drug

Glybubin is an antidiabetic drug, used to lower the sugar level in the blood of the patient having non insulin dependent diabetes. It belongs to a class of sulfonylureas.

Indications and Usage

Glibenclamide is a popular anti-diabetic agent, which is widely used for treating type II diabetes. Type II diabetes begins with insulin resistance, a state in which cells fail to respond to insulin properly.

Dosage and Administration

1. Recommended dose

The dosage should be adapted to each patient and is determined by the results of the medical analysis. The suggested initial dose is 2.5 mg daily. The daily dose can then be increased gradually in steps, but only after repeated medical examination. Increasing the doses beyond three tablets daily would not produce any increased response.

2. Method of Administration

The tablets should be taken orally with or immediately after breakfast. When you buy Glybuvin 5 mg online, make a note of the administration instructions mentioned here. Also, follow the directions given by your doctor.

3. Missed dose

If a dose is missed, take it as soon as you remember, do not take two doses at the same time. 

4. Overdose

If you think you or someone else has overdosed, get medical help right away. An accidental overdose of Glibenclamide may cause low blood sugar, which results in faintness, sickness, cold, sweat, and palpitation.

Forms and Strengths

Glibenclamide is a drug that is available in the form of a tablet. You can buy Glibenclamide in the following strengths from our website:

 Glybuvin 5 mg
 Semi Daonil 2.5 mg
 Diabetrol 5 + 500 mg

Buy Glybuvin 5 mg online from reliablerxpharmacy.com at a much lower price.

Contraindications

The drug Glibenclamide is contraindicated in patients with:

 Known hypersensitivity or allergy to the drug
 Type 1 diabetes
 Diabetic ketoacidosis, with or without coma. This health issue should be treated with insulin

Warnings and precautions

 Almost all sulfonylureas are capable of producing severe hypoglycemia. Proper dosage selection and instructions are important to avoid hypoglycemic episodes. Hepatic or renal insufficiency may cause elevated drug levels of Glibenclamide, and the latter may also decrease glucogenic capacity, both of which increase the risk of serious hypoglycemic reactions. Elderly, malnourished patients, and those with pituitary or adrenal insufficiency are particularly susceptible to the hypoglycemic action of glucose-lowering medicines. Hypoglycemia may be difficult to identify in elderly and with people who are taking beta-adrenergic blocking agents.

 When a patient stabilized on any diabetic treatment is exposed to stress such as trauma, infection, fever, or surgery, a loss of control may occur. At such times, it may be essential to discontinue the drug and administer insulin. Adherence to diet and adequate adjustment of dose should be assessed before classifying the patient as a secondary failure.

 It has been suggested that the abnormal blood glucose levels during pregnancy are associated with a higher incidence of fetal abnormalities, doctors recommend that insulin is used during pregnancy to maintain glucose levels as close to normal as possible.

 Although it is not known whether the drug is excreted in mother’s milk, some sulfonylurea drugs are known to be excreted in mother’s milk. Because of the potential for hypoglycemia in nursing babies, a decision should be made whether to discontinue the medicine or to discontinue nursing, taking into account the importance of Glibenclamide to the mother.

Side effects

The side effects reported most frequently at the recommended dose of Glibenclamide are:
 Allergic reaction
 Swelling of the lips, face, or neck
 Decreased blood cell
 Problem in vision
 Loss of appetite
 Diarrhea
 Feeling sick
 Vomiting
 Burning chest pain
 Low sodium concentration in blood

The side effects of this medication are not restricted to the ones mentioned above. Inform your doctor right away if you observe any unwanted non-therapeutic effect.

Drug Interactions

These are the drugs that can alter the pharmacological effect of Glibenclamide:
 Chloramphenicol
 Cimetidine
 Quinolone antibiotic
 Fluconazole
 Sulfonamide salicylates
Ask your doctor and get the full list of drugs that may increase the possibility of drug interactions or interfere with the effectiveness of Glibenclamide.

Ingredients

Glibenclamide is the main active ingredient present in Glybuvin tablets. It works by inhibiting ATP-sensitive potassium channels in pancreatic beta cells. This action causes depolarization, the opening of voltage-dependent calcium channels, thus cause an increase in intracellular calcium in the beta cell, which stimulates the release of insulin.

Storage information

Glibenclamide should be stored in a safe place that is away from heat and moisture. Do not refrigerate. Keep the drug out of the reach of children and pets. Do not keep the medicine out in the open.

Manufacturer

Glybuvin 5 mg is manufactured by Sun Pharmaceutical Industries Ltd., a pharmaceutical company, which is an Indian multinational company headquartered in Maharashtra. You can easily buy Glybuvin 5 mg online from our website and have it delivered to your doorstep.