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Megalis (Tadalafil) is an oral drug, used for treating male impotence, also known as erectile men's erectile dysfunction. Megalis effect starts working in 30 minutes and lasts for about 48 hours, while Viagra effect lasts fot about 4 hours. Megalis is to be taken with or without food. Megalis is to be used for daily use, so you can be ready anytime.